Digestive enzymes play an integral role in digestion. Pancreatic enzymes are the most important among other enzymes and they help to breakdown proteins, fats and carbohydrates. Breakdown and absorption of macronutrients primarily takes place in the small intestine and is mediated by adequate production of pancreatic protease (to digest proteins), amylase (to digest carbohydrates) and lipase (to digest fats) and lactase (to digest lactose). Restoring levels and activity of digestive enzymes may support healthy digestive function.
Digestive enzymes used in the ZyMate works on specific substrates under specific conditions of temperature, pH and water. The gastrointestinal pH profiles of healthy subjects have been taken into consideration while formulating the ZyMate – multi-enzyme complex. The intraluminal pH is rapidly changed from highly acidic (1.5 to 3.5) in the stomach to about pH 6 in the duodenum. The pH gradually increases in the small intestine from pH 6 to about pH 7.4 in the terminal ileum. The pH drops to 5.7 in the caecum, but again gradually increases, reaching pH 6.7 in the rectum.
ZyMate is a multi-enzyme complex currently available into 3 variants principally consists of key enzymes responsible for digestion of nutrients for various health conditions. These enzymes include amylase, neutral protease, acid protease, lactase, lipase, Invertase, maltase, pectinase, phytase and cellulase.
Neutral protease and acidic proteases used in ZyMate is a proteolytic enzyme derived from a selected strain of Bacillus subtilis/licheniformis. Proteases assist in breakdown of proteins into amino acids which are absorbed in blood streams. Amino acids are known for their role in building muscle growth and repairing muscle tissues.
Lipase used in ZyMate is a triacylglycerol lipase obtained from the fungus Rhizopus oryzae and Aspergillus oryzae. Lipase enzymes are essential for hydrolysis of fats and oils to yield free fatty acid, partial glycerides and glycerol. Depending on the type of fats consumed essential fatty acids such as omega 3, omega 6 fatty acids are absorbed in human body for various functions. Long chain fatty acids are hydrolysed via metabolic pathway to provide energy.
Alpha (α) amylases used in ZyMate is produced by fermentation process using selected strain of Aspergillus oryzae. Alpha amylases play a key role in hydrolysing carbohydrates by breaking the alpha 1, 4 glycosidic linkages in amylose and amylopectin components of carbohydrates, resulting in the production of dextrins, maltose and other simple sugars.
Lactase also known as Beta-D-galactosidase used in ZyMate is produced by fermentation process using selected strain of Aspergillus oryzae. Lactase helps in hydrolysis of lactose into its glucose and galactose which are easily digested and absorbed in human body. External supplements consisting of Lactase help those individuals who have the inability to digest lactose found in dairy products commonly known as Lactose intolerance. Commercially lactase is also used in the production of lactose free dairy products. Supply of lactases will allow individuals suffering from lactose intolerance to relish range of dairy products without side effects.
It is an enzyme derived from selected strain of Trichoderma reesei. Cellulase assist
in hydrolysis of complex carbohydrates including cellulose, hemicellulose, lichenin,
beta-glucan and arabinoxylans into simple sugars or shorter polysaccharides and oligosaccharides.
It is also known as beta-fructofuranosidase used in ZyMate is derived from yeast (Saccharomyces cerevisiae) and helps to hydrolyse common sugar (sucrose) in to glucose and fructose which is vital for digestion of sugars.
Maltase used in ZyMate is produced from a selected strain of saccharomyces cerevisiae and helps to break down of disaccharide maltose into two glucose units.
Pectinase used in ZyMate is produced from a selected strain of Aspergillus niger and helps in hydrolysing pectins. Pectinases are naturally found in various fruits (e.g. apples) and play a key role in digestion and healthy living and longevity.
Phytase used in ZyMate is produced from a selected strain of Aspergillus niger and has the ability to release bound minerals present in various plants phytic form e.g. phytic phosphate. Phytase enzyme is one of the most essential enzymes required for digestion process. Hydrolysis of phytates to release essential minerals such as phosphorus, calcium, zinc, iron and magnesium is essential for their abortion in human body.
All enzymes used in ZyMate multi-enzyme complexes are protected against gastric juices and are standardized as per FCC units, a brief description of enzymes and their testing units are given below:
- Amylase – SKB (Alpha-amylase-Dextrinizing Units); also called DU Units.
- Glucoamylase – AGU (Amyloglucosidase Units)
- Protease - HUT (Haemoglobin Unit Tyrosine base)
- Lipase – FIP (Lipase Units)
- Lactase – ALU (Acid Lactase Unit)
- Cellulase - CU (Cellulase Unit)
- Bromelain – GDU (Gelatin Digesting Units)
- Glucoamylase or AGU (also AU or AG) (Amylo-Glucosidase Units)
- Invertase – SU (Sumner Units)
- Maltase - DP (Degrees Diastaic Power)
- Pectinase - Endo-PGU (Endo-Polygalacturnonase Units)
- Alpha Galactosidase – GAL
The Conversation between FCC and USP enzyme activity units is as follows:
|Amylase||1 DU OR SKB||48 units|
|Protease||1 HUT||0.61 PC Units|
|Lipase||1 LU OR 0.1 FIP||6.3 USP Units|
|Lactase||1 ALU||1 LACU Units|
|Cellulase||1 CU||1 CU|
|Bromelain||1 FIP OR 500 GDU||7462.68 PU Units|
|Invertase||1 FCC IAU = 500 SU||1 USP IAU|